5,6-Dihydro-5-Fluorouracil-13C,15N2
Selected Variant
HY-134160S-01
Size: 500 µg
5,6-Dihydro-5-Fluorouracil-13C,15N2 (5-DHFU-13C,15N2) is the 13C- and 15N-labeled labeled 5,6-Dihydro-5-Fluorouracil. 5,6-Dihydro-5-Fluorouracil (5-DHFU; 5-Fluorodihydropyrimidine-2,4-dione) is the active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil (HY-90006), which is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-Dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC50=13.5 μM). Intravenous administration of 5,6-Dihydro-5-Fluorouracil (90 mg/kg/wk) in combination with 5-fluorouracil and the DPD inhibitor eniluracil (HY-10533) slows tumor growth in a rat colon cancer model.
Product Specifications
CAS Number
1189492-99-6
Product Name Alternative
5-DHFU-13C,15N2; 5-Fluorodihydropyrimidine-2,4-dione-13C,15N2; 5-Fluorodihydrouracil-13C,15N2
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
O=C1C(C[15NH][13C]([15NH]1)=O)F
Molecular Formula
C3 13CH5F 15N2O2
Molecular Weight
135.07
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Price
Frequently Asked Questions
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