2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate (sodium)
2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium (2'-fluoro dATP) is a fluorinated derivative of ATP. 2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium is a substrate and an inhibitor for E.coli DNA-dependent RNA polymerase, with a Ki of 200 µM[1].
Product Specifications
Product Name Alternative
2'-Fluoro dATP (sodium)
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O=P(O[Na])(O[Na])OP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](F)[C@@H]1O)(O[Na])=O)(O[Na])=O
Molecular Formula
C10H11FN5Na4O12P3
Molecular Weight
597.10
References & Citations
[1]Ishihama A, et al. 2'-Deoxy-2'-azidoadenosine triphosphate and 2'-deoxy-2'-fluoroadenosine triphosphate as substrates and inhibitors for Escherichia coli DNA-dependent RNA polymerase. J Biochem. 1980 Mar;87 (3) :825-30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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