2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate (sodium)

2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium (2'-fluoro dATP) is a fluorinated derivative of ATP (HY-B2176) . 2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium is a substrate and an inhibitor for E.coli DNA-dependent RNA polymerase, with a Ki of 200 µM[1].

Product Specifications

Product Name Alternative

2'-Fluoro dATP (sodium)

UNSPSC

12352005

Target

Nucleoside Antimetabolite/Analog

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

O=P(O[Na])(O[Na])OP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](F)[C@@H]1O)(O[Na])=O)(O[Na])=O

Molecular Formula

C10H11FN5Na4O12P3

Molecular Weight

597.10

References & Citations

[1]Ishihama A, et al. 2'-Deoxy-2'-azidoadenosine triphosphate and 2'-deoxy-2'-fluoroadenosine triphosphate as substrates and inhibitors for Escherichia coli DNA-dependent RNA polymerase. J Biochem. 1980 Mar;87 (3) :825-30.