Varespladib-d7

Varespladib-d7 (LY315920-d7) is a deuterated labeled Varespladib (HY-13402) . Varespladib is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively[1].

Product Specifications

CAS Number

[1360701-64-9]

Product Name Alternative

LY315920-d7

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Phospholipase

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Inflammation/Immunology

Smiles

O=C(O)COC1=CC=CC2=C1C(C(C(N)=O)=O)=C(CC)N2C([2H])([2H])C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H]

Molecular Formula

C21H13D7N2O5

Molecular Weight

387.44

References & Citations

[1]Snyder DW, et al. Pharmacology of LY315920/S-5920, [[3- (aminooxoacetyl) -2-ethyl-1- (phenylmethyl) -1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. J Pharmacol Exp Ther. 1999 Mar;288 (3) :1117-24.