Bimakalim
Bimakalim (EMD-52692) is an ATP-sensitive potassium channel opener. Bimakalim reduces transmural MPO activity. Bimakalim mimics the effects of ischemic preconditioning to reduce infarct size, adenosine release, and neutrophil function in dogs[1].
Product Specifications
CAS Number
117545-11-6
Product Name Alternative
EMD-52692; SR-44866
UNSPSC
12352005
Target
Glutathione Peroxidase; Potassium Channel
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cardiovascular Disease
Smiles
N#CC1=CC=C2C(C(N3C=CC=CC3=O)=CC(C)(C)O2)=C1
Molecular Formula
C17H14N2O2
Molecular Weight
278.31
References & Citations
[1]Mizumura T, et al. Bimakalim, an ATP-sensitive potassium channel opener, mimics the effects of ischemic preconditioning to reduce infarct size, adenosine release, and neutrophil function in dogs. Circulation. 1995 Sep 1;92 (5) :1236-45.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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