Bimakalim

Bimakalim (EMD-52692) is an ATP-sensitive potassium channel opener. Bimakalim reduces transmural MPO activity. Bimakalim mimics the effects of ischemic preconditioning to reduce infarct size, adenosine release, and neutrophil function in dogs[1].

Product Specifications

CAS Number

[117545-11-6]

Product Name Alternative

EMD-52692; SR-44866

UNSPSC

12352005

Target

Glutathione Peroxidase; Potassium Channel

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cardiovascular Disease

Smiles

N#CC1=CC=C2C(C(N3C=CC=CC3=O)=CC(C)(C)O2)=C1

Molecular Formula

C17H14N2O2

Molecular Weight

278.31

References & Citations

[1]Mizumura T, et al. Bimakalim, an ATP-sensitive potassium channel opener, mimics the effects of ischemic preconditioning to reduce infarct size, adenosine release, and neutrophil function in dogs. Circulation. 1995 Sep 1;92 (5) :1236-45.