I-AZD1775 (TFA)

I-AZD1775 (TFA) is an immobilizable analogue of AZD1775. i-AZD1775 (TFA) retains the ability to inhibit WEE1 in vitro. i-AZD1775 (TFA) can be studied in anticancer research[1].

Product Specifications

CAS Number

[2858813-30-4]

UNSPSC

12352005

Target

Wee1

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

O=C(C(F)(F)F)O.O=C1C2=CN=C(NC3=CC=C(N4CCN(CCCN)CC4)C=C3)N=C2N(N1CC=C)C5=CC=CC(C(C)(C)O)=N5

Molecular Formula

C31H38F3N9O4

Molecular Weight

657.69

References & Citations

[1]Wright, G., et al., (2017) . Dual Targeting of WEE1 and PLK1 by AZD1775 Elicits Single Agent Cellular Anticancer Activity. ACS chemical biology, 12 (7), 1883–1892.