1,1,3-Tribromoacetone (Standard)

1,1,3-Tribromoacetone (Standard) is the analytical standard of 1,1,3-Tribromoacetone. This product is intended for research and analytical applications. 1,1,3-Tribromoacetone is an impurity of Methotrexate (HY-14519) [1]. Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1].

Product Specifications

CAS Number

[3475-39-6]

UNSPSC

12352211

Target

Drug Metabolite; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Smiles

O=C(CBr)C(Br)Br

Molecular Formula

C3H3Br3O

Molecular Weight

294.77

References & Citations

[1]Balwant Singh, et al. Process for the preparation of high purity methotrexate and derivatives thereof. Patent US4374987A 87A|[2][2].Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58 (4) :473-92|[3]Banji D, et al. Evaluation of the concomitant use of methotrexate and curcumin on Freund's complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol. 2011;43 (5) :546-550.