4-Formylaminoantipyrine-d3

4-Formylaminoantipyrine-d3 is the deuterium labeled 4-Formylaminoantipyrine (HY-133588) . 4-Formylaminoantipyrine is an excreted metabolite of Aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo[1].

Product Specifications

UNSPSC

12352005

Target

Endogenous Metabolite; Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Metabolic Disease

Purity

99.71

Solubility

10 mM in DMSO

Smiles

O=CNC1=C(C)N(C([2H])([2H])[2H])N(C2=CC=CC=C2)C1=O

Molecular Formula

C12H10D3N3O2

Molecular Weight

234.27

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]M Levy, et al. Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis B virus. Clin Pharmacol Ther|[3]A Noda, et al.Formation of 4-formylaminoantipyrine as a new metabolite of aminopyrine. II. Enzymatic demethylation and oxidation of aminopyrine and 4-monomethylaminoantipyrine. Chem Pharm Bull (Tokyo) .1976 Dec;24 (12) :3229-31.|[4]David do C Malvar, et al. Dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2 -dependent and -independent fever while 4-AA only blocks PGE2 -dependent fever. Br J Pharmacol. 2014 Aug;171 (15) :3666-79.