ARN23765
ARN23765 is a corrector for F508del-CFTR with an EC50 of 38 pM in human bronchial epithelial cells. ARN23765 improves the maturation and function of F508del-CFTR on the cell membrane, affects the ions transport and secretion, and corrects the pathological mechanism of cystic fibrosis (CF) [1].
Product Specifications
UNSPSC
12352005
Target
CFTR
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Others
Smiles
OC(C1=CC=C(C=C1)O[C@H]2CCCC3=C2N(N=C3C(F)(F)F)C4=CC(C(N(C)C5=CC6=C(OC(F)(F)O6)C=C5)=O)=CC=C4)=O
Molecular Formula
C30H22F5N3O6
Molecular Weight
615.50
References & Citations
[1]Pedemonte N, et al., Discovery of a picomolar potency pharmacological corrector of the mutant CFTR chloride channel. Sci Adv. 2020 Feb 21;6 (8) :eaay9669.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-133569/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
CAS Number
[2244458-40-8]
Curated Selection
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