ARN23765

ARN23765 is a corrector for F508del-CFTR with an EC50 of 38 pM in human bronchial epithelial cells. ARN23765 improves the maturation and function of F508del-CFTR on the cell membrane, affects the ions transport and secretion, and corrects the pathological mechanism of cystic fibrosis (CF) [1].

Product Specifications

CAS Number

[2244458-40-8]

UNSPSC

12352005

Target

CFTR

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Others

Smiles

OC(C1=CC=C(C=C1)O[C@H]2CCCC3=C2N(N=C3C(F)(F)F)C4=CC(C(N(C)C5=CC6=C(OC(F)(F)O6)C=C5)=O)=CC=C4)=O

Molecular Formula

C30H22F5N3O6

Molecular Weight

615.50

References & Citations

[1]Pedemonte N, et al., Discovery of a picomolar potency pharmacological corrector of the mutant CFTR chloride channel. Sci Adv. 2020 Feb 21;6 (8) :eaay9669.