VSP-77
VSP-77 is an orally active PPARγ agonist. VSP-77 selectively upregulates the expression of insulin sensitivity-related genes (Glut4 and Adiponectin) by inhibiting CDK5-mediated phosphorylation of PPARγ at Ser-273. VSP-77 significantly improves glucose tolerance, reduces fasting blood glucose and insulin levels in high-fat diet (HFD) -induced diabetic mouse models. VSP-77 can be used for the study of diabetes[1].
Product Specifications
CAS Number
1854008-12-0
UNSPSC
12352005
Target
PPAR
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Smiles
ClC1=CC=C(C(CCCCCCC)OCC(O)=O)C=C1
Molecular Formula
C16H23ClO3
Molecular Weight
298.81
References & Citations
[1]Jiang H, et al. Identification and structural insight of an effective PPARγ modulator with improved therapeutic index for anti-diabetic drug discovery. Chem Sci. 2020 Jan 21;11 (8) :2260-2268.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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