VSP-77

VSP-77 is an orally active PPARγ agonist. VSP-77 selectively upregulates the expression of insulin sensitivity-related genes (Glut4 and Adiponectin) by inhibiting CDK5-mediated phosphorylation of PPARγ at Ser-273. VSP-77 significantly improves glucose tolerance, reduces fasting blood glucose and insulin levels in high-fat diet (HFD) -induced diabetic mouse models. VSP-77 can be used for the study of diabetes[1].

Product Specifications

CAS Number

[1854008-12-0]

UNSPSC

12352005

Target

PPAR

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Metabolic Disease

Smiles

ClC1=CC=C(C(CCCCCCC)OCC(O)=O)C=C1

Molecular Formula

C16H23ClO3

Molecular Weight

298.81

References & Citations

[1]Jiang H, et al. Identification and structural insight of an effective PPARγ modulator with improved therapeutic index for anti-diabetic drug discovery. Chem Sci. 2020 Jan 21;11 (8) :2260-2268.