Maleimide-DOTA (GMP)

Maleimide-DOTA (Maleimido-mono-amide-DOTA) (GMP) is Maleimide-DOTA (HY-133540) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Maleimide-DOTA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

Product Specifications

CAS Number

[1006711-90-5]

Product Name Alternative

Maleimido-mono-amide-DOTA (GMP)

UNSPSC

12352211

Target

ADC Linker

Related Pathways

Antibody-drug Conjugate/ADC Related

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(NCCN2C(C=CC2=O)=O)=O)CC1

Molecular Formula

C22H34N6O9

Molecular Weight

526.54

References & Citations

[1]Tavaré R, et al. Enhanced immunoPET of ALCAM-positive colorectal carcinoma using site-specific ⁶⁴Cu-DOTA conjugation. Protein Eng Des Sel. 2014 Oct;27 (10) :317-24.