Tetrazine-Ph-NHCO-C3-NHS ester
Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Tetrazine-Ph-NHCO-C3-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
Product Specifications
CAS Number
[1244040-64-9]
UNSPSC
12352005
Hazard Statement
H302
Target
PROTAC Linkers
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.40
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CCCC(ON1C(CCC1=O)=O)=O)NCC2=CC=C(C3=NN=CN=N3)C=C2
Molecular Formula
C18H18N6O5
Molecular Weight
398.37
Precautions
H302
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers
Available Sizes
Curated Selection
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