Methyltetrazine-PEG5-methyltetrazine

Methyltetrazine-PEG5-methyltetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Methyltetrazine-PEG5-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

Product Specifications

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.79

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=NN=C(C2=CC=C(CNC(CCOCCOCCOCCOCCOCCC(NCC3=CC=C(C4=NN=C(C)N=N4)C=C3)=O)=O)C=C2)N=N1

Molecular Formula

C34H44N10O7

Molecular Weight

704.78

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

Available Sizes

Curated Selection

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