Cyclazosin (hydrochloride)
Cyclazosin hydrochloride is an α1B-adrenergic receptor antagonist. Cyclazosin hydrochloride has high specificity for α-adrenergic receptors, with pKi values of 9.23-9.57 and 8.18-8.41 for O/1A (O/la) and OflB (alb) adrenergic receptors, respectively. However, Cyclazosin hydrochloride cannot distinguish between cloned alb and alo adrenergic receptors, which have pKi values of 9.23 and 9.28, respectively[1].
Product Specifications
CAS Number
[146929-33-1]
UNSPSC
12352005
Target
Adrenergic Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Cardiovascular Disease
Smiles
COC1=CC2=NC(N3CCN(C(C4=CC=CO4)=O)[C@@]5([H])CCCC[C@@]35[H])=NC(N)=C2C=C1OC.Cl
Molecular Formula
C23H28ClN5O4
Molecular Weight
473.95
References & Citations
[1]D Giardinà, et al. Receptor binding profile of cyclazosin, a new alpha 1B-adrenoceptor antagonist. Eur J Pharmacol. 1995 Dec 4;287 (1) :13-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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