IIIM-1266
IIIM-1266 is a NLRP3 inflammasome inhibitor. IIIM-1266 inhibits IL-1β release in mouse macrophages (J774A.1 cells) (IC50 = 2.3 μM) and significantly reduced the protein expression level of mature IL-1β. IIIM-1266 can be used for the study of inflammation[1].
Product Specifications
CAS Number
[2468202-93-7]
UNSPSC
12352005
Target
Interleukin Related; NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
O=S(C1=C2C(C3=CC=C2)C(NC3=O)C=C1)(N(CC)CC)=O
Molecular Formula
C15H18N2O3S
Molecular Weight
306.38
References & Citations
[1]Abdullaha M, et al. Discovery of benzo[cd]indol-2-one and benzylidene-thiazolidine-2,4-dione as new classes of NLRP3 inflammasome inhibitors via ER-β structure based virtual screening. Bioorg Chem. 2020 Jan;95:103500.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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