N-Desmethylnefopam-d5

N-Desmethylnefopam-d5 is the deuterium labeled N-Desmethylnefopam (HY-133115) . N-Desmethylnefopam is the main metabolite of Nefopam. N-Desmethylnefopam is a centrally-acting but non-opioid analgesic agent, for the relief of moderate to severe pain. Nefopam targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo[1][2][3].

Product Specifications

CAS Number

[2748500-28-7]

UNSPSC

12352005

Target

Isotope-Labeled Compounds; β-catenin

Related Pathways

Others; Stem Cell/Wnt

Field of Research

Neurological Disease

Smiles

[2H]C1=C([2H])C(C2C(C=CC=C3)=C3CNCCO2)=C([2H])C([2H])=C1[2H]

Molecular Formula

C16H12D5NO

Molecular Weight

244.34

References & Citations

[1]Mittur A. A Simultaneous Mixed-Effects Pharmacokinetic Model for Nefopam, N-desmethylnefopam, and Nefopam N-Oxide in Human Plasma and Urine. Eur J Drug Metab Pharmacokinet. 2018 Aug;43 (4) :391-404.|[2]Kim KH, et al. Rediscovery of nefopam for the treatment of neuropathic pain. Korean J Pain. 2014 Apr;27 (2) :103-11.|[3]Baht GS, et al. Pharmacologically targeting beta-catenin for NF1 associated deficiencies in fracture repair. Bone. 2017 May;98:31-36.