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Regorafenib (Hydrochloride) (Standard)

Regorafenib (Hydrochloride) (Standard) is the analytical standard of Regorafenib (Hydrochloride) . This product is intended for research and analytical applications. Regorafenib Hydrochloride (BAY 73-4506 hydrochloride) is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively[1].

Product Specifications

CAS Number

835621-07-3

UNSPSC

12352100

Target

Autophagy; PDGFR; Raf; Reference Standards; RET; VEGFR

Related Pathways

Autophagy; MAPK/ERK Pathway; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

ClC1=C(C(F)(F)F)C=C(NC(NC2=C(F)C=C(OC3=CC=NC(C(NC)=O)=C3)C=C2)=O)C=C1.Cl

Molecular Formula

C21H16Cl2F4N4O3

Molecular Weight

519.28

References & Citations

[1]Wilhelm SM, et al. Regorafenib (BAY 73-4506) : a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer, 2011, 129 (1), 245-255.|[2]Heng DY, et al. Targeted therapy for metastatic renal cell carcinoma: current treatment and future directions. Ther Adv Med Oncol, 2010, 2 (1), 39-49.|[3]Carr BI, et al. Fluoro-Sorafenib (Regorafenib) effects on hepatoma cells: growth inhibition, quiescence, and recovery. J Cell Physiol, 2013, 228 (2), 292-297.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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