Hydrodolasetron
Hydrodolasetron is a metabolite of Dolasetron. Hydrodolasetron is more potent than Dolasetron in inhibiting nAChR. Hydrodolasetron is a 5-HT (3A) R blocker with an IC50 of 0.29 nM. Hydrodolasetron has antiemetic activity[1].
Product Specifications
CAS Number
127951-99-9
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
5-HT Receptor; nAChR
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Smiles
O=C(C1=CNC2=C1C=CC=C2)OC3CC4N5CC(O)C(C4)CC5C3
Molecular Formula
C19H22N2O3
Molecular Weight
326.39
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Paul M, et al. Antiemetics of the 5-hydroxytryptamine 3A antagonist class inhibit muscle nicotinic acetylcholine receptors. Anesth Analg. 2005 Sep;101 (3) :715-721.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Available Sizes
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