Ascorbyl tetra-2-hexyldecanoate

Ascorbyl tetra-2-hexyldecanoate (tetra-isopalmitoyl Ascorbic acid; IPAA) is a lipophilic derivative of vitamin C (L-ascorbic acid) . Ascorbyl tetra-2-hexyldecanoate (100 μM) can prevent the decrease in viability of HaCaT keratinocytes induced by UVB, hydrogen peroxide, or tert-butyl hydroperoxide, and reduce the production of IL-1α and prostaglandin E2 (PGE2) . Topical application of ascorbyl tetra-2-hexyldecanoate (1%) increases epidermal viability thickness, stratum corneum water content, and skin smoothness, and reduces skin roughness in hairless mice. Ascorbyl tetra-2-hexyldecanoate can be used to develop skin whitening agents in the beauty industry.

Product Specifications

CAS Number

[183476-82-6]

Product Name Alternative

Tetra-isopalmitoyl Ascorbic acid; IPAA; Tetrahexyldecyl Ascorbate

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Prostaglandin Receptor

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Purity

98.0

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C1O[C@H]([C@@H](OC(C(CCCCCC)CCCCCCCC)=O)COC(C(CCCCCC)CCCCCCCC)=O)C(OC(C(CCCCCC)CCCCCCCC)=O)=C1OC(C(CCCCCC)CCCCCCCC)=O

Molecular Formula

C70H128O10

Molecular Weight

1129.76

Precautions

H315, H319

References & Citations

[1]Ochiai, et al. A new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), prevents UV-induced skin pigmentation through its anti-oxidative properties. J. Dermatol. Sci. 44 (1), 37-44 (2006) .