Desacetylvinblastine
Desacetylvinblastine (4-Desacetylvinblastine) is the major metabolite of Vinblastine and a cytotoxic agent. When used alone, desacetylvinblastine has poor anti-tumor effects, but it can exert significant anti-tumor activity when in the presence of specific conjugates[1].
Product Specifications
CAS Number
3352-69-0
Product Name Alternative
4-Desacetylvinblastine; Desacetylvincaleukoblastine
UNSPSC
12352005
Hazard Statement
H302-H341-H361
Target
Drug Metabolite
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
CC[C@]1(O)C[C@]2([H])C[C@@](C3=C(OC)C=C(N([C@]4([H])[C@@]56[C@]7([H])[C@](C=CCN7CC6)(CC)[C@@H](O)[C@@]4(C(OC)=O)O)C)C5=C3)(C(OC)=O)C8=C(CC[N@@](C2)C1)C9=CC=CC=C9N8
Molecular Formula
C44H56N4O8
Molecular Weight
768.94
Precautions
P264-P270-P280-P330-P405-P501
References & Citations
[1]Brady SF, et al. Design and synthesis of a pro-drug of vinblastine targeted at treatment of prostate cancer with enhanced efficacy and reduced systemic toxicity. J Med Chem. 2002 Oct 10;45 (21) :4706-15.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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