Ivospemin (hydrochloride)

Ivospemin (SBP-101) hydrochloride is an antineoplastic spermine analog. Ivospemin hydrochloride has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin hydrochloride shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin hydrochloride is promising for research of cancers[1][2][3].

Product Specifications

CAS Number

[259657-09-5]

Product Name Alternative

SBP-101 (hydrochloride)

UNSPSC

12352211

Target

Drug Derivative

Related Pathways

Others

Field of Research

Cancer

Smiles

CCNCC[C@H](O)CNCCCCNC[C@@H](O)CCNCC.Cl.Cl.Cl.Cl

Molecular Formula

C16H42Cl4N4O2

Molecular Weight

464.34

References & Citations

[1]Holbert CE, et al. The Polyamine Analogue Ivospemin hydrochloride Increases Chemotherapeutic Efficacy in Murine Ovarian Cancer. Biomedicines. 2024 May 23;12 (6) :1157. |[2]Liu TA, et al. The Synergistic Benefit of Combination Strategies Targeting Tumor Cell Polyamine Homeostasis. Int J Mol Sci. 2024 Jul 26;25 (15) :8173. |[3]International Nonproprietary Names for Pharmaceutical Substances (INN) .