Ivospemin (hydrochloride)
Ivospemin (SBP-101) hydrochloride is an antineoplastic spermine analog. Ivospemin hydrochloride has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin hydrochloride shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin hydrochloride is promising for research of cancers[1][2][3].
Product Specifications
CAS Number
[259657-09-5]
Product Name Alternative
SBP-101 (hydrochloride)
UNSPSC
12352211
Target
Drug Derivative
Related Pathways
Others
Field of Research
Cancer
Smiles
CCNCC[C@H](O)CNCCCCNC[C@@H](O)CCNCC.Cl.Cl.Cl.Cl
Molecular Formula
C16H42Cl4N4O2
Molecular Weight
464.34
References & Citations
[1]Holbert CE, et al. The Polyamine Analogue Ivospemin hydrochloride Increases Chemotherapeutic Efficacy in Murine Ovarian Cancer. Biomedicines. 2024 May 23;12 (6) :1157. |[2]Liu TA, et al. The Synergistic Benefit of Combination Strategies Targeting Tumor Cell Polyamine Homeostasis. Int J Mol Sci. 2024 Jul 26;25 (15) :8173. |[3]International Nonproprietary Names for Pharmaceutical Substances (INN) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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