Lumacaftor (Standard)
Lumacaftor (Standard) is the analytical standard of Lumacaftor. This product is intended for research and analytical applications. Lumacaftor (VX-809; VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.
Product Specifications
UNSPSC
12352100
Target
Autophagy; CFTR; Reference Standards
Related Pathways
Autophagy; Membrane Transporter/Ion Channel; Others
Field of Research
Inflammation/Immunology
Smiles
FC1(F)OC(C=C(C=C2)C3(CC3)C(NC4=NC(C5=CC=CC(C(O)=O)=C5)=C(C=C4)C)=O)=C2O1
Molecular Formula
C24H18F2N2O5
Molecular Weight
452.41
References & Citations
[1]Van Goor F, et al. Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809. Proc Natl Acad Sci U S A. 2011 Nov 15;108 (46) :18843-8.|[2]Phuan PW, et al. Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy. Mol Pharmacol. 2014 Jul;86 (1) :42-51.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13262R/
Scientific Category
Reference Standards
CAS Number
[936727-05-8]
Available Sizes
Curated Selection
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