RPR121056-d3
RPR121056-d3 is the deuterium labeled RPR121056. RPR121056 is a metabolite of Irinotecan , which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE[1][2].
Product Specifications
CAS Number
1217816-76-6
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Isotope-Labeled Compounds; Topoisomerase
Related Pathways
Cell Cycle/DNA Damage; Neuronal Signaling; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
C(C([2H])([2H])[2H])C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(OC(=O)N6CCC(NCCCCC(O)=O)CC6)=CC5
Molecular Formula
C33H35D3N4O8
Molecular Weight
621.70
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Alvau MD, et al. Enzyme-Based Electrochemical Biosensor for Therapeutic Drug Monitoring of Anticancer Drug Irinotecan. Anal Chem. 2018 May 15;90 (10) :6012-6019.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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