BOC-D-FMK (Standard)
BOC-D-FMK (Standard) is the analytical standard of BOC-D-FMK. This product is intended for research and analytical applications. Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor. Boc-D-FMK inhibits apoptosis stimulated by TNF-α with an IC50 of 39 μM.
Product Specifications
CAS Number
634911-80-1
UNSPSC
12352100
Target
Apoptosis; Caspase; Reference Standards
Related Pathways
Apoptosis; Others
Field of Research
Cancer
Smiles
O=C(CC(C(CF)=O)NC(OC(C)(C)C)=O)OC
Molecular Formula
C11H18FNO5
Molecular Weight
263.26
References & Citations
[1]Cowburn AS, et al. z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species.|[2]Yee SB, et al. zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells. Exp Mol Med. 2006 Dec 31;38 (6) :634-42.|[3]Sheen-Chen SM, et al. Effect of Boc-D-Fmk on hepatocyte apoptosis after bile duct ligation in rat and survival rate after endotoxin challenge. J Gastroenterol Hepatol. 2008 Aug;23 (8 Pt 1) :1276-9.|[4]Chan YM, et al. Inhibition of caspases promotes long-term survival and reinnervation by axotomized spinal motoneurons of denervated muscle in newborn rats. Exp Neurol. 2003 Jun;181 (2) :190-203.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
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