Chloramphenicol 1-acetate

Chloramphenicol 1-acetate (Compound III) is a microbial transformation product of Chloramphenicol (HY-B0239) by Streptomyces coelicolor. Chloramphenicol 1-acetate is the major product of Chloramphenicol acetyltransferase I (CATI) by regioselective acetylation of C21 hydroxy groups in steroids[1].

Product Specifications

CAS Number

[23214-93-9]

UNSPSC

12352005

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Smiles

ClC(Cl)C(N[C@H](CO)[C@@H](C1=CC=C(C=C1)[N+]([O-])=O)OC(C)=O)=O

Molecular Formula

C13H14Cl2N2O6

Molecular Weight

365.17

References & Citations

[1]Argoudelis AD, et al. Microbial transformation of antibiotics. VI. Acylation of chloramphenicol by Streptomyces coelicolor. J Antibiot (Tokyo) . 1971 Mar;24 (3) :206-8.|[2]Mosa A, et al. Regioselective Acetylation of C21 Hydroxysteroids by the Bacterial Chloramphenicol Acetyltransferase I. Chembiochem. 2015 Jul 27;16 (11) :1670-9.