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MTEP (hydrochloride) (Standard)

MTEP (hydrochloride) (Standard) is the analytical standard of MTEP (hydrochloride) . This product is intended for research and analytical applications. MTEP hydrochloride is a potent, non-competitive and highly selective mGluR5 antagonist, with an IC50 of 5 nM and a Ki of 16 nM. MTEP hydrochloride shows antidepressant and anxiolytic-like effects. MTEP hydrochloride can be used for Parkinson's disease research[1][2][3][4].

Product Specifications

CAS Number

1186195-60-7

UNSPSC

12352100

Target

MGluR; Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

CC1=NC(C#CC2=CC=CN=C2)=CS1.[H]Cl

Molecular Formula

C11H9ClN2S

Molecular Weight

236.72

References & Citations

[1]Lea PM 4th, et al. Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP. CNS Drug Rev. 2006 Summer;12 (2) :149-66.|[2]Ossowska K, et al. MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats. Neuropharmacology. 2005 Sep;49 (4) :447-55.|[3]Pałucha A, et al. Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist. Pharmacol Biochem Behav. 2005 Aug;81 (4) :901-6.|[4]Klodzinska A, et al. Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA (A) signaling. Neuropharmacology. 2004 Sep;47 (3) :342-50.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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