Mal-Val-Ala-PAB (C2-glucuronic acid) -DMEA-PNU-159682
Selected Variant
HY-132031
Size: 1 Each
Mal-Val-Ala-PAB (C2-glucuronic acid) -DMEA-PNU-159682 is an active molecule-conjugate for ADCs, composed of a cleavable Val-Ala linker and the potent ADC cytotoxic payload PNU-159682.
Product Specifications
CAS Number
2682939-53-1
UNSPSC
12352005
Target
Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related
Field of Research
Cancer
Smiles
OC1=C2C(C(C(C(OC)=CC=C3)=C3C2=O)=O)=C(O)C4=C1C[C@](C(COC(N(C)CCN(C)C(OCC5=CC=C(NC([C@H](C)NC([C@H](C(C)C)NC(CN6C(C=CC6=O)=O)=O)=O)=O)C=C5CC[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O7)=O)=O)=O)(O)C[C@@H]4O[C@H]8C[C@H](N(CCO[C@@H]9OC)[C@@H]9O%10)[C@H]%10[C@H](C)O8
Molecular Formula
C67H81N7O27
Molecular Weight
1416.39
References & Citations
[1]Holte D, et al. Evaluation of PNU-159682 antibody drug conjugates (ADCs) . Bioorg Med Chem Lett. 2020 Dec 15;30 (24) :127640.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Price
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