T0070907 (Standard)
T0070907 (Standard) is the analytical standard of T0070907. This product is intended for research and analytical applications. T0070907 is a potent PPARγ antagonist with a Ki of 1 nM.
Product Specifications
CAS Number
313516-66-4
UNSPSC
12352100
Target
PPAR; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
ClC1=C(C=C(C=C1)[N+]([O-])=O)C(NC2=CC=NC=C2)=O
Molecular Formula
C12H8ClN3O3
Molecular Weight
277.66
References & Citations
[1]An Z, et al. T0070907 inhibits repair of radiation-induced DNA damage by targeting RAD51. Toxicol In Vitro. 2016 Dec;37:1-8|[2]An Z, et al. T0070907, a PPAR γ inhibitor, induced G2/M arrest enhances the effect of radiation in human cervical cancer cells through mitotic catastrophe. Reprod Sci. 2014 Nov;21 (11) :1352-61.|[3]Kawahara A, et al. Peroxisome proliferator-activated receptor γ (PPARγ) -independent specific cytotoxicity against immature adipocytes induced by PPARγ antagonist T0070907. Biol Pharm Bull. 2013;36 (9) :1428-34|[4]Lee G, et al. T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. J Biol Chem. 2002 May 31;277 (22) :19649-57. Epub 2002 Mar 4
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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