Ganglioside GT1b (porcine) (ammonium)

Ganglioside GT1b (porcine) ammonium is a member of the ganglioside family. Ganglioside GT1b (porcine) ammonium acts as a protective signal against nerve injury-induced spinal synapse elimination. Ganglioside GT1b (porcine) ammonium induces HA synthesis and the phosphorylation of Akt/mTOR in orbital fibroblasts. Ganglioside GT1b (porcine) ammonium enhances porcine oocyte maturation and induces activation of EGFR and ERK1/2 signaling. Ganglioside GT1b (porcine) ammonium is a putative host cell receptor for the Merkel cell polyomavirus. Ganglioside GT1b (porcine) ammonium can be used for the researches of cancer, infection, immunology, endocrinology and neurological disease, such as Thyroid eye disease[1][2][3][4].

Product Specifications

CAS Number

[59247-13-1]

UNSPSC

12352005

Target

Akt; EGFR; ERK; mTOR

Related Pathways

JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer; Infection; Inflammation/Immunology; Metabolic Disease; Neurological Disease

Purity

Smiles

O[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1OC[Ceramide])CO)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O[C@@H]3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O[C@]5(C(O)=O)C[C@@H]([C@H]([C@@H](O5)[C@H](O)[C@H](O)CO)NC(C)=O)O)O)O)CO)O[C@]6(C(O)=O)C[C@@H]([C@H]([C@@H](O6)[C@H](O)[C@H](O[C@]7(C(O)=O)C[C@@H]([C@H]([C@@H](O7)[C@H](O)[C@H](O)CO)NC(C)=O)O)CO)NC(C)=O)O)O)O.N.N.N

References & Citations

[1]Lee J, et al. Ganglioside GT1b prevents selective spinal synapse removal following peripheral nerve injury. EMBO Rep. 2025 Jun;26 (12) :2994-3023. |[2]Yoo HK, et al. Ganglioside GT1b increases hyaluronic acid synthase 2 via PI3K activation with TLR2 dependence in orbital fibroblasts from thyroid eye disease patients. BMB Rep. 2021 Feb;54 (2) :136-141.|[3]Kim JW, et al. Exogenous Ganglioside GT1b Enhances Porcine Oocyte Maturation, Including the Cumulus Cell Expansion and Activation of EGFR and ERK1/2 Signaling. Reprod Sci. 2020 Jan;27 (1) :278-289. |[4]Erickson KD, et al. Ganglioside GT1b is a putative host cell receptor for the Merkel cell polyomavirus. J Virol. 2009 Oct;83 (19) :10275-9.