Ganglioside GT1b (bovine) (ammonium)

Ganglioside GT1b is a member of the ganglioside family. Ganglioside GT1b acts as a protective signal against nerve injury-induced spinal synapse elimination. Ganglioside GT1b induces HA synthesis and the phosphorylation of Akt/mTOR in orbital fibroblasts. Ganglioside GT1b enhances porcine oocyte maturation and induce activation of EGFR and ERK1/2 signaling. Ganglioside GT1b is a putative host cell receptor for the Merkel cell polyomavirus. Ganglioside GT1b can be used for the researches of cancer, infection, immunology, endocrinology and neurological disease, such as Thyroid eye disease[1][2][3][4].

Product Specifications

CAS Number

[59247-13-1]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Akt; EGFR; ERK; mTOR

Related Pathways

JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Infection; Endocrinology; Inflammation/Immunology; Neurological Disease

Purity

98.0

Smiles

O[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1OC[Ceramide])CO)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O[C@@H]3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O[C@]5(C(O)=O)C[C@@H]([C@H]([C@@H](O5)[C@H](O)[C@H](O)CO)NC(C)=O)O)O)O)CO)O[C@]6(C(O)=O)C[C@@H]([C@H]([C@@H](O6)[C@H](O)[C@H](O[C@]7(C(O)=O)C[C@@H]([C@H]([C@@H](O7)[C@H](O)[C@H](O)CO)NC(C)=O)O)CO)NC(C)=O)O)O)O.N.N.N

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee J, et al. Ganglioside GT1b prevents selective spinal synapse removal following peripheral nerve injury. EMBO Rep. 2025 Jun;26 (12) :2994-3023.|[2]Yoo HK, et al. Ganglioside GT1b increases hyaluronic acid synthase 2 via PI3K activation with TLR2 dependence in orbital fibroblasts from thyroid eye disease patients. BMB Rep. 2021 Feb;54 (2) :136-141.|[3]Kim JW, et al. Exogenous Ganglioside GT1b Enhances Porcine Oocyte Maturation, Including the Cumulus Cell Expansion and Activation of EGFR and ERK1/2 Signaling. Reprod Sci. 2020 Jan;27 (1) :278-289.|[4]Erickson KD, et al. Ganglioside GT1b is a putative host cell receptor for the Merkel cell polyomavirus. J Virol. 2009 Oct;83 (19) :10275-9.