5'-Azido-5'-deoxythymidine

5'-Azido-5'-deoxythymidine (Compound 7), a nucleoside analogue, is a reverse transcriptase inhibitor. 5'-Azido-5'-deoxythymidine mimics nucleosides and is incorporated into the viral DNA chain to terminate chain elongation, inhibiting viral replication. 5'-Azido-5'-deoxythymidine is promising for research of retroviral infection diseases such as AIDS[1][2].

Product Specifications

CAS Number

[19316-85-9]

UNSPSC

12352005

Target

Reverse Transcriptase

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(C(C)=CN1[C@H]2C[C@H](O)[C@@H](CN=[N+]=[N-])O2)NC1=O

Molecular Formula

C10H13N5O4

Molecular Weight

267.24

References & Citations

[1]Neenan JP, Rohde W. Inhibition of thymidine kinase from Walker 256 carcinoma by thymidine analogs. J Med Chem. 1973 May;16 (5) :580-1.|[2]Baraniak D. Synthesis of nucleoside-cinchona alkaloid conjugates via" click" chemistry[D]. Zakład Chemii Medycznej [nowa struktura organizacyjna], 2012.