Cidofovir diphosphate-13C3
Cidofovir diphosphate-13C3 is the 13C-labeled Cidofovir diphosphate (HY-131606) . Cidofovir diphosphate is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate is a selective inhibitor of viral DNA polymerases with Ki values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively[1][2].
Product Specifications
UNSPSC
12352005
Target
CMV; HSV; Isotope-Labeled Compounds
Related Pathways
Anti-infection; Others
Field of Research
Infection
Smiles
O=P(O)(O)OP(OP(CO[13C@H]([13CH2]O)[13CH2]N1C(N=C(C=C1)N)=O)(O)=O)(O)=O
Molecular Formula
C5 13C3H16N3O12P3
Molecular Weight
442.12
References & Citations
[1]Hitchcock MJM, et al. Cidofovir, a New Agent with Potent Anti-Herpesvirus Activity. 1996. |[2]Magee WC, et al. Mechanism of inhibition of vaccinia virus DNA polymerase by cidofovir diphosphate. Antimicrob Agents Chemother. 2005 Aug;49 (8) :3153-62.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Curated Selection
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