Ganciclovir triphosphate (disodium)
Ganciclovir triphosphate (GCV-TP) disodium is a synthetic 2'-deoxyguanosine analog with activity in inhibiting human cytomegalovirus (CMV) replication. Ganciclovir triphosphate disodium is effective against CMV infection by binding to viral DNA polymerase and interfering with viral DNA synthesis. Ganciclovir triphosphate disodium has an IC50 of 0.01 μM against CMV strains from humans, monkeys, mice, and guinea pigs. Ganciclovir triphosphate disodium has also been used in gene-directed enzyme prodrug inhibition for cancer inhibition[1].
Product Specifications
Product Name Alternative
GCV-TP (disodium)
UNSPSC
12352005
Target
CMV; DNA/RNA Synthesis
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Concentration
100 mM * 100 μL in Water
Purity
98.65
Smiles
O=P(O)(OP(O)(OP(O)(O)=O)=O)OCC(OCN1C=NC2=C1N=C(N)NC2=O)CO.[Na].[Na]
Molecular Formula
C9H16N5Na2O13P3
Molecular Weight
541.15
References & Citations
[1]Sawdon AJ, et al. Polymeric Nanovectors Incorporated with Ganciclovir and HSV- tk Encoding Plasmid for Gene-Directed Enzyme Prodrug Therapy
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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