6-Thio-GTP (tetrasodium)
6-Thio-GTP (tetrasodium) is a Vav1-Rac inhibitor. 6-Thio-GTP (tetrasodium) inhibits TCR-stimulated T cell proliferation and CD28-mediated T cell survival. 6-Thio-GTP (tetrasodium) has an immunosuppressive effect in a mouse cardiac allograft transplant model and prolongs cardiac allograft survival[1].
Product Specifications
Product Name Alternative
6-Thioguanosine-5'-triphosphate (tetrasodium)
UNSPSC
12352005
Target
Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Concentration
10 mM * 79.72 μL in Water
Purity
99.7
Smiles
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2NC(N)=NC3=S)O[C@@H]1COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O
Molecular Formula
C10H12N5Na4O13P3S
Molecular Weight
627.17
References & Citations
[1]Wang S, et al. Enhanced cardiac allograft survival by Vav1-Rac signaling blockade in a mouse model. Transpl Immunol. 2007 Jul;18 (1) :53-61.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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