8-Oxo-GTP

8-Oxo-GTP is an oxidized oxidized guanine nucleotides and acts as a crucial biomarker for oxidative stress.

Product Specifications

CAS Number

[21238-36-8]

Product Name Alternative

8-Hydroxyguanosine triphosphate

UNSPSC

12352005

Target

Reactive Oxygen Species (ROS)

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

O[C@H]1[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3N=C2O)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O

Molecular Formula

C10H16N5O15P3

Molecular Weight

539.18

References & Citations

[1]Patil AG, Sang PB, Govindan A, Varshney U. Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) proteins constitute a two-stage mechanism of 8-oxo-dGTP and 8-oxo-GTP detoxification and adenosine to cytidine mutation avoidance. J Biol Chem. 2013 Apr 19;288 (16) :11252-62. doi: 10.1074/jbc.M112.442566. Epub 2013 Mar 5. PMID: 23463507; PMCID: PMC3630869.|[2]Li Y, Wang X. The role of DNA and RNA guanosine oxidation in cardiovascular diseases. Pharmacol Res. 2024 Jun;204:107187. doi: 10.1016/j.phrs.2024.107187. Epub 2024 Apr 23. PMID: 38657843.