NAI-802

NAI-802 is a new lantibiotic. NAI-802 can be produced by Actinoplanes sp. NAI-802 shows a significant activity against Gram-positive anaerobic bacteria, such as Clostridium difficile, C. butyricum, C. perfringens and Peptostreptococcus asaccharolyticus with MIC ranges of 0.25-2 μg/mL[1].

Product Specifications

CAS Number

[1426209-02-0]

UNSPSC

12352005

Target

Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(N[C@H](C(N[C@@H](CSC[C@H]1NC([C@@H](N)C)=O)C(N[C@H]([C@@H](SC[C@](C(NCC(N[C@@]([C@@H]([S](C[C@H]2C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)C)([H])C(N[C@H]3C(C)C)=O)=O)=O)([H])NC([C@@H](NC4=O)CCC(O)=O)=O)C)C(N[C@H](C(N[C@@]([C@@H](SC[C@](C(N[C@H](C(N2)=O)C)=O)([H])NC([C@](NC3=O)([H])[C@@H](C)CC)=O)C)([H])C(N[C@@]4([H])[C@@H](C)CC)=O)=O)CC(C)C)=O)=O)=O)C(C)C)[C@](NC(CNC([C@](NC1=O)([H])CO)=O)=O)([H])CC5=CNC6=CC=CC=C56

Molecular Formula

C90H141N25O26S4

Molecular Weight

2117.49

References & Citations

[1]Simone M, et al. Isolation and characterization of NAI-802, a new lantibiotic produced by two different Actinoplanes strains. J Antibiot (Tokyo) . 2013 Feb;66 (2) :73-8.