ASN-1377642
ASN-1377642 is a NK1 receptor antagonist with a Ki value of 251 nM. ASN-1377642 shows antitumor action in breast cancer cells with NK1R-Tr high expression[1][2].
Product Specifications
CAS Number
337505-63-2
UNSPSC
12352005
Target
Neurokinin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Cancer
Purity
90.000000
Smiles
O=C(NC1=CC=CC(Cl)=C1)CSC2=NN=C(C3=CC=NC=C3)N2C4=CC=CC=C4
Molecular Formula
C21H16ClN5OS
Molecular Weight
421.90
References & Citations
[1]Zhou Y, et al. Roles of full-length and truncated neurokinin-1 receptors on tumor progression and distant metastasis in human breast cancer. Breast Cancer Res Treat. 2013 Jul;140 (1) :49-61.|[2]Evers A, et al. Ligand-supported homology modeling of g-protein-coupled receptor sites: models sufficient for successful virtual screening. Angew Chem Int Ed Engl. 2004 Jan;43 (2) :248-51.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NK1R
Available Sizes
Frequently Asked Questions
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