GI-149893
GI-149893 is a selective topoisomerase I (TopoI) inhibitor. GI-149893 prevents DNA religation and induces irreversible DNA damage in tumor cells. GI-149893 is promising for research of cancers (e.g., colon carcinoma HT-29/SW-48, breast MX-1, prostate PC-3 xenografts) [1][2].
Product Specifications
CAS Number
149809-18-7
UNSPSC
12352005
Target
Topoisomerase
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(CN5CCN(C)CC5)C6=CC7=C(OCO7)C=C6N=C4C3=C2)=O
Molecular Formula
C27H28N4O6
Molecular Weight
504.53
References & Citations
[1]Emerson DL, et al. In vivo antitumor activity of two new seven-substituted water-soluble camptothecin analogues. Cancer Res. 1995 Feb 1;55 (3) :603-9.|[2]Fan Y, et al. Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecin. J Med Chem. 1998 Jun 18;41 (13) :2216-26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo I
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