DS37571084

DS37571084 is an orally active and potent antagonist of the parathyroid hormone type 1 receptor (PTHR1), with an IC50 value of 0.17 μM. DS37571084 can be used for the study of hyperparathyroidism[1].

Product Specifications

CAS Number

2460353-87-9

UNSPSC

12352005

Target

PTHR

Related Pathways

GPCR/G Protein

Field of Research

Endocrinology; Metabolic Disease

Smiles

O=C1N(C2=CC=C(NCCNC3CCOCC3)C=C2)C4=CC(Cl)=CC=C4C5=CC(Cl)=CN=C5C1(C)C

Molecular Formula

C28H30Cl2N4O2

Molecular Weight

525.47

References & Citations

[1]Arai Y, et al. Discovery of novel, potent, and orally bioavailable pyrido[2,3-d][1]benzazepin-6-one antagonists for parathyroid hormone receptor 1. Bioorg Med Chem. 2020 Jun 1;28 (11) :115524.