DS37571084
DS37571084 is an orally active and potent antagonist of the parathyroid hormone type 1 receptor (PTHR1), with an IC50 value of 0.17 μM. DS37571084 can be used for the study of hyperparathyroidism[1].
Product Specifications
CAS Number
[2460353-87-9]
UNSPSC
12352005
Target
PTHR
Related Pathways
GPCR/G Protein
Field of Research
Endocrinology; Metabolic Disease
Smiles
O=C1N(C2=CC=C(NCCNC3CCOCC3)C=C2)C4=CC(Cl)=CC=C4C5=CC(Cl)=CN=C5C1(C)C
Molecular Formula
C28H30Cl2N4O2
Molecular Weight
525.47
References & Citations
[1]Arai Y, et al. Discovery of novel, potent, and orally bioavailable pyrido[2,3-d][1]benzazepin-6-one antagonists for parathyroid hormone receptor 1. Bioorg Med Chem. 2020 Jun 1;28 (11) :115524.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PTH1R
Curated Selection
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