DPTIP (hydrochloride)
DPTIP hydrochloride is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM[1][2].
Product Specifications
CAS Number
[2361799-64-4]
UNSPSC
12352005
Target
Phospholipase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology; Others
Smiles
OC1=C(OC)C=C(C2=NC(C3=CC=CC=C3)=C(C4=CC=CS4)N2)C=C1OC.Cl
Molecular Formula
C21H19ClN2O3S
Molecular Weight
414.91
References & Citations
[1]Camilo Rojas, et al. DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Sci Rep. 2018 Dec 7;8 (1) :17715.|[2]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35 (1) :1322-1330.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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