Tetrazine-PEG4-amine (hydrochloride)
Tetrazine-PEG4-amine (hydrochloride) is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Tetrazine-PEG4-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
Product Specifications
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.83
Solubility
Methanol : 250 mg/mL (ultrasonic)
Smiles
NCCOCCOCCOCCOCCC(NCC1=CC=C(C2=NN=CN=N2)C=C1)=O.[H]Cl
Molecular Formula
C20H31ClN6O5
Molecular Weight
470.95
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-130977/Tetrazine-PEG4-amine-hydrochloride-SDS-MedChemExpress.pdf
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker
CAS Number
[2752945-36-9]
Available Sizes
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