Amino-PEG4-bis-PEG3-methyltetrazine

Amino-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Amino-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

Product Specifications

UNSPSC

12352203

Hazard Statement

H302-H315-H319-H335

Target

ADC Linker

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Solubility

10 mM in DMSO

Smiles

NCCOCCOCCOCCOCCC(NC(COCCC(NCCOCCOCCOCCNC(CC1=CC=C(C2=NN=C(C)N=N2)C=C1)=O)=O)COCCC(NCCOCCOCCOCCNC(CC3=CC=C(C4=NN=C(C)N=N4)C=C3)=O)=O)=O

Molecular Formula

C58H90N14O17

Molecular Weight

1255.42

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.

Shipping Conditions

Room temperature

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Cleavable Linker

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MG201053 10 µg

Adm2 (NM_182928) Mouse Tagged ORF Clone

Ask

View Details

GTR15155407 1 Vial

Lentiviral human MAPK8IP2 shRNA (UAS) - Lentiviral human MAPK8IP2 shRNA (UAS) plasmid

Ask

View Details

HK200984 1 Kit

ATP6V1H Human qPCR Template Standard (NM_015941)

Ask

View Details

NBP2-34702IR 0.1 mL

Mouse Monoclonal TGF-alpha Antibody (P/T1) [DyLight 755]

Ask

View Details