Vrucaparib-TP4
Vrucaparib-TP4 (Compound 9) is a PARP1 PROTAC-type degrader. Vrucaparib-TP4 promotes the ubiquitination and degradation of PARP1. Vrucaparib-TP4 can be used in the research of tumors[1].
Product Specifications
CAS Number
2410557-03-6
UNSPSC
12352005
Target
PARP; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1NCCC2=C(NC3=CC(F)=CC1=C32)C4=CC=C(C=C4)CN(CCCCC5=CN(N=N5)CCOCCOCCOCCOCCC(N[C@H](C(N6C[C@@H](C[C@H]6C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)O)=O)C(C)(C)C)=O)C
Molecular Formula
C58H75FN10O9S
Molecular Weight
1107.34
References & Citations
[1]Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15 (12) :1223-1231.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1
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