7-Hydroxymethotrexate (sodium)

7-Hydroxymethotrexate sodium is a major metabolite of Methotrexate. Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2].

Product Specifications

UNSPSC

12352211

Target

Drug Metabolite

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O=C(O[Na])CC[C@@H](C(O[Na])=O)NC(C(C=C1)=CC=C1N(C)CC2=NC(C(N)=NC(N)=N3)=C3N=C2O[Na])=O

Molecular Formula

C20H19N8Na3O6

Molecular Weight

536.38

References & Citations

[1]L Fahrig, et al. Pharmacokinetics of methotrexate (MTX) and 7-hydroxymethotrexate (7-OH-MTX) in rats and evidence for the metabolism of MTX to 7-OH-MTX. Cancer Chemother Pharmacol. 1989;23 (3) :156-60.|[2]Ping Guo, et al. Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2007 Apr 11;43 (5) :1789-95.