7-Hydroxymethotrexate (sodium)
7-Hydroxymethotrexate sodium is a major metabolite of Methotrexate. Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2].
Product Specifications
UNSPSC
12352211
Target
Drug Metabolite
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O=C(O[Na])CC[C@@H](C(O[Na])=O)NC(C(C=C1)=CC=C1N(C)CC2=NC(C(N)=NC(N)=N3)=C3N=C2O[Na])=O
Molecular Formula
C20H19N8Na3O6
Molecular Weight
536.38
References & Citations
[1]L Fahrig, et al. Pharmacokinetics of methotrexate (MTX) and 7-hydroxymethotrexate (7-OH-MTX) in rats and evidence for the metabolism of MTX to 7-OH-MTX. Cancer Chemother Pharmacol. 1989;23 (3) :156-60.|[2]Ping Guo, et al. Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2007 Apr 11;43 (5) :1789-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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