SL-3-19
SL-3-19 is a tubulin ligand. SL-3-19 exhibits antitumor activity against esophageal squamous cell carcinoma (ESCC) both in vitro and in vivo by inhibiting microtubule assembly, inducing G2/M phase cell cycle arrest and apoptosis, and disrupting tumor blood vessels. SL-3-19 has a higher activity than SL-1-73. SL-3-19 can be used for the research of ESCC and other tumors[1].
Product Specifications
CAS Number
2000199-45-9
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=S(NC1=CC=C(OC)N=C1OC)(C2=CC=C3C(C4=C(N3C)C=C(O)C=C4)=C2)=O
Molecular Formula
C20H19N3O5S
Molecular Weight
413.45
References & Citations
[1]Niu F, et al. Novel carbazole sulfonamide microtubule-destabilizing agents exert potent antitumor activity against esophageal squamous cell carcinoma. Cancer Lett. 2018 Apr 28;420:60-71.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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