Tetrazine-Ph-PEG5-NHS ester

Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Tetrazine-Ph-PEG5-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

Product Specifications

CAS Number

[1682653-80-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.29

Solubility

10 mM in DMSO

Smiles

O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCC(NCC2=CC=C(C3=NN=CN=N3)C=C2)=O

Molecular Formula

C27H36N6O10

Molecular Weight

604.61

Precautions

H302, H315, H319, H335

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562