SB-773812
SB-773812 is a moderate-affinity antagonist at dopamine receptor 2 (pKi=7.4) and a high-affinity antagonist at the dopamine receptor 3 (pKi=8.5) and at the serotonin 5-hydroxytryptamine receptors 2A (pKi=9.0), 2C (pKi=8.1), and 6 (pKi=8.1) . SB-773812 is promising for research of central nervous system disorders[1][2].
Product Specifications
CAS Number
630407-66-8
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
CN1CCC2=CC(OC)=C(S(=O)(C3=CC=C(OCC4=CC=C(Cl)C=C4)C=C3)=O)C=C2CC1
Molecular Formula
C25H26ClNO4S
Molecular Weight
472.00
References & Citations
[1]Garg A, et al. Amit Garg A Mechanism Based Population Pharmacokinetic-Pharmacodynamic Model for Epoetin Alfa and Darbepoetin Alfa in Chronic Kidney Disease Patients[J]. Poster Abstracts PAGE 2010, 47.|[2]Catafau AM, et al. Contribution of SPECT measurements of D2 and 5-HT2A occupancy to the clinical development of the antipsychotic SB-773812. J Nucl Med. 2011 Apr;52 (4) :526-34.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor;5-HT6 Receptor; D2 Receptor; D3 Receptor
Frequently Asked Questions
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