Fostamatinib Disodium (Standard)

Fostamatinib Disodium (Standard) is the analytical standard of Fostamatinib Disodium. This product is intended for research and analytical applications. Fostamatinib Disodium (R788 Disodium) is the oral proagent of the active compound R406[1]. R406 is an orally available and competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM[2]. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM) [3].

Product Specifications

CAS Number

[1025687-58-4]

UNSPSC

12352100

Target

FLT3; Reference Standards; Syk

Related Pathways

Others; Protein Tyrosine Kinase/RTK

Field of Research

Inflammation/Immunology; Cancer

Smiles

COC1=CC(NC2=NC=C(C(NC3=NC(N4COP(O[Na])(O[Na])=O)=C(C=C3)OC(C)(C)C4=O)=N2)F)=CC(OC)=C1OC

Molecular Formula

C23H24FN6Na2O9P

Molecular Weight

624.42

References & Citations

[1]Stephen P McAdoo, et al. Fostamatinib Disodium. Drugs Future. 2011;36 (4) :273.|[2]Sylvia Braselmann, et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther. 2006 Dec;319 (3) :998-1008.|[3]Hoon-Suk Cha , et al. A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes. J Pharmacol Exp Ther. 2006 May;317 (2) :571-8.